Open TAC Gallery

A public evidence-topology diagnostic library for structural target validation across mechanistic (T), genetic (Φ), and clinical (Σ) evidence layers.
Omega Infinity does not summarize literature consensus. It evaluates whether cross-layer evidence forms a stable causal topology.
Each case shows where target-validation structure converges into validated alignment, fractures across evidence layers, or remains unresolved at the translational frontier before clinical outcomes fully settle.
The purpose of the Open TAC Gallery is not to identify promising targets, but to expose where translational structure is incomplete, fragile, or internally inconsistent across evidence layers.
Validated alignment
Mechanistic logic, human genetics, and clinical intervention converge into stable causal topology with low translational uncertainty.
Structural fracture
Mechanistic plausibility present but causal anchoring collapses under human translation constraints.
Consensus-risk frontier
Targets with strong scientific enthusiasm but incomplete topology closure across intervention layers.
Consensus stress cases
Situations where mechanistic enthusiasm exceeds cross-layer intervention stability. Topology signals translation-boundary uncertainty before clinical consensus shifts.

TAC Index
PCSK9 — genetic cardiometabolic alignment
TNF — causal cytokine intervention paradigm
IL23 — pathway-selective immunology success
BACE1 — translation boundary collapse archetype
TREM2 — microglial intervention-direction uncertainty
LRRK2 — kinase safety topology frontier
STING — innate immune activation durability risk